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          Recombinant Human IL-23 Protein
           
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          產(chǎn)品說(shuō)明書(shū)
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
           
          


          IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells.
          


           
          


          性能參數(shù)
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          Interleukin-23
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          Sf 21 (baculovirus)
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Apparent molecular mass of 65 kDa, 43-45 kDa and 20 kDa in SDS-PAGE under reducing conditions.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          Human IL-23 p40（Ile23-Ser328）&Human IL-23 p19 (Ala21-Pro189, Accession # AAG37232)
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          Measured by its ability to induce IL-17 secretion by mouse splenocytes. The ED50 for this effect is 0.05-0.3 ng/mL..
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 95% by SDS-PAGE.
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          <1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from 0.2 μm filtered concentrated sterile solution in 20 mM MES, pH 6.0, 500 mM NaCl and 1 mM EDTA.
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          


          儲(chǔ)存條件
          


          The product should be stored at -25~-15℃ for 1 year from date of receipt.
          


          1 month, 2 ~8 °C under sterile conditions after reconstitution.
          


          3 months, -25~-15℃ under sterile conditions after reconstitution.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          注意事項(xiàng)
          


          1.Please operate with lab coats and disposable gloves,for your safety.
          


          2.This product is for research use only. 
          


          Ver. CN20230508
          

             
           
           
           
           
           
           
           
          400-6111-883