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          Biotinylated Human VEGF R1/FLT-1 Protein, His-Avi Tag
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          

           
          


          VEGFR1, also called Flt-1, is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs). Human VEGFR1 ECD shares 78%, 78%, 84%, 87%, and 90% aa sequence identity with mouse, rat, porcine, canine and equine VEGFR1, respectively. VEGFR1 is up regulated during hypoxia, and participates in neovascularization and wound healing. VEGFR1 engagement on monocyte/macrophage lineage cells enhances their migration, and release of growth factors and cytokines. Lymphangiogenesis, angiogenesis, and growth-promoting effects of VEGFR1 are thought to result from enhanced migration of macrophages from the bone marrow to tumors and tissues where they recruit endothelial progenitors. 
          


           
          


          產(chǎn)品性質(zhì)
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          FLT; FLT1; Flt-1; FRT; VEGF R1; VEGFR1
          
			          		
		
          
		
          
			
			
          Uniprot No.
          
			          		
			
			
          P17948-1
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          Recombinant Biotinylated Human VEGF R1/FLT-1 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Ser27-Asn756.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          The protein has a predicted MW of 85.1 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 95% as determined by SDS-PAGE
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          Centrifuge tubes before opening. Reconstituting to a concentration more than 100μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
          
			          		
		
          
	          

          


           
          


          運(yùn)輸與保存方法
          


          The products are shipped with ice pack and can be stored at -20℃ for 1 year.
          


          2-7 days, 2 to 8 °C under sterile conditions after reconstitution.
          
3 -6 months, -20 to -80°C under sterile conditions after reconstitution.
          


          Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles.
          


           
          


          注意事項(xiàng)
          


            
	
          1. For your safety and health, please wear lab coats and disposable gloves for operation.
            2. 
	
          2. For research use only!
            3. 

          

          


           
          


          產(chǎn)品數(shù)據(jù)
          


          


           
          


          HB230112
          

             
           
           
           
           
           
           
           
          400-6111-883