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          Recombinant SARS-COV-2 Spike S1 Protein,His Tag
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          

           
          


          SARS-CoV-2 Spike Protein (S Protein) is a glycoprotein that mediates membrane fusion and viral entry. The S Protein of the SARS-CoV-2 virus binds Angiotensin-Converting Enzyme 2 (ACE-2), but with much higher affinity and faster binding kinetics . Polyclonal antibodies to the RBD of the SARS-CoV-2 S1 subunit have been shown to inhibit interaction with the ACE-2 receptor, confirming RBD as an attractive target for vaccinations or antiviral therapy . There is also promising work showing that the RBD may be used to detect presence of neutralizing antibodies present in a patient's bloodstream, consistent with developed immunity after exposure to the SARS-CoV-2 virus. Lastly, it has been demonstrated the S Protein can invade host cells through the CD147/EMMPRIN receptor and mediate membrane fusion. 
          


           
          


          產(chǎn)品性質(zhì)
          


          
	
		
          
			
			
          別名
          
			          		
			
			
          S1 protein; Spike protein S1; Spike,S1 protein; S glycoprotein Subunit1
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          QHO60594.1
          
			          		
		
          
		
          
			
			
          表達(dá)區(qū)間及表達(dá)系統(tǒng)
          
			          		
			
			
          Recombinant SARS-COV-2 Spike S1 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Gln14-Arg683.
          
			          		
		
          
		
          
			
			
          分子量
          
			          		
			
			
          Approximately 76.1 kDa. Due to glycosylation, the protein migrates to 115-140 kDa based on Tris-Bis PAGE result.
          
			          		
		
          
		
          
			
			
          純度
          
			          		
			
			
          > 95% as determined by SDS-PAGE and HPLC.
          
			          		
		
          
		
          
			
			
          活性
          
			          		
			
			
          ELISA Data：Immobilized SARS-COV-2 Spike S1, His Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Human ACE2, hFc Tag with the EC50 of 19.4ng/ml determined by ELISA.
          
			          		
		
          
		
          
			
			
          內(nèi)毒素
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          制劑
          
			          		
			
			
          Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
          
			          		
		
          
		
          
			
			
          復(fù)溶
          
			          		
			
			
          Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.
          
			          		
		
          
	          

          


           
          


          運(yùn)輸與保存方法
          


          冰袋運(yùn)輸。-20℃保存，一年有效期。
          


          復(fù)溶后，-20 °C，在未開封狀態(tài)下保存 3-6 個(gè)月。復(fù)溶后，2-8°C 保存 2-7 天。
          


          建議第一次使用時(shí)分裝凍存，避免反復(fù)凍融。
          


           
          

          


          注意事項(xiàng)
          


            
	
          1. 避免反復(fù)凍融。
            2. 
	
          2. 為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。
            3. 
	
          3. 本產(chǎn)品僅作科研用途！
            4. 

          


           
          


          產(chǎn)品數(shù)據(jù)
          


          


          


          HB221025
          

             
           
           
           
           
           
           
           
          400-6111-883