问鼎娱乐.com|极速飞艇的冠亚和计划|极速赛车计划群群名|sg幸运飞艇计划官方版下载

<label id="6kt4j"></label>

    <li id="6kt4j"></li>
    1. 

          2. 
    
            
           
           
           
           
          Recombinant Mouse BRAK/CXCL14
           
          更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
           
           
           
          批量采購(gòu)， 請(qǐng)點(diǎn)擊詢價(jià)
           
           
          產(chǎn)品說(shuō)明書(shū)
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          Chemokine (C-X-C motif) ligand 14 (CXCL14), also named BRAK, is a small cytokine belonging to the CXC chemokine family. Recombinant mouse CXCL14 contains 77 amino acid residues and it shares 97 % and 99 % a.a. sequence identity with human and rat CXCL14. CXCL14 serves as a chemoattractant for activated macrophages, immature dendritic cells and natural killer cells, as well as an antiangiogenic factor by preventing the migration of endothelial cells. CXCL14 also exerts an inhibitory effect on the CXCL12/ CXCR4 signaling pathway, which is involved in the maintenance of T‐helper (Th)2 bias, and promotes Th1 immune response under the physiological and pathological conditions. CXCL14 has been shown to be a highly selective chemoattractant for monocytes that have been treated with prostaglandin E2 or forskolin, agents that activate adenylate cyclase.
          


           
          


          Product Properties
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          B-cell and Monocyte-activating Chemokine, Chemokine BRAK, Kidney-expressed Chemokine CXC, CXCL14, MIP-2G, Small-inducible Cytokine B14
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          Q9WUQ5
          
			          		
		
          
		
          
			
			
          GeneID
          
			          		
			
			
          57266
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          E.coli-derived mouse BRAK/CXCL14 protein, Ser23-Glu99.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Approximately 9.4 kDa.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
          
			          		
		
          
		
          
			
			
          Tag
          
			          		
			
			
          None
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          >95% by SDS-PAGE and HPLC analyses.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/mL. Fully biologically active when compared to standard. 
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 400 mM NaCl, pH 7.4, 5% trehalose.
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          


          Shipping and Storage
          


          The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          Cautions
          


          1. Avoid repeated freeze-thaw cycles.
          


          2. For your safety and health, please wear lab coats and disposable gloves for operation.
          


          3. For research use only!
          


           
          


          HB220402
          


           
          

             
           
           
           
           
           
           
           
          400-6111-883