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          Recombinant Mouse PF-4/CXCL4
           
          更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
           
           
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          CXCL4, also called PF4, is a small cytokine belonging to the CXC chemokine family and it is also known as chemokine (C-X-C motif) ligand. Mature mouse CXCL4 shares 76%, 88%, 64%, 64% and 63% amino acid sequence identity with human, rat, ovine, porcine and bovine CXCL4, respectively. Recombinant mouse CXCL4 contains 76 amino acids which is a single non-glycosylated polypeptide chain. CXCL4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF-2 and VEGF heparin binding and thus inhibiting their signaling. Tumor tissue revealed up-regulation of CXCL14 in cancer-associated fibroblasts of a majority of prostate cancer. Fibroblasts overexpressing CXCL14 promoted the growth of prostate cancer xenografts, and increased tumor angiogenesis and macrophage infiltration. 
          


           
          


          Product Properties
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          chemokine (C-X-C motif) ligand 4, C-X-C motif chemokine 4, CXCL4, CXCL4iroplact, Iroplact, MGC138298, Oncostatin-A, PF4, platelet factor 4
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          Q9Z126
          
			          		
		
          
		
          
			
			
          GeneID
          
			          		
			
			
          56744
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          E.coli-derived mouse PF-4/CXCL4 protein, Val30-Ser105.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Approximately 8.2 kDa.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES
          
			          		
		
          
		
          
			
			
          Tag
          
			          		
			
			
          None
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          >97% by SDS-PAGE and HPLC analyses.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration of 10-100ng/ml. Fully biologically active when compared to standard. 
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 1.5 M NaCl, pH 7.4.
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          


          Shipping and Storage
          


          The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          Cautions
          


          1. Avoid repeated freeze-thaw cycles.
          


          2. For your safety and health, please wear lab coats and disposable gloves for operation.
          


          3. For research use only!
          


           
          


          HB220331
          

             
           
           
           
           
           
           
           
          400-6111-883