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          Recombinant Human HB-EGF Protein重組人肝素結(jié)合性表皮生長因子
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻
                  
           
          Human HB-EGF (Heparin-Binding EGF-like growth factor), also known as the DTR (diphtheria toxin receptor), is a 12-16 kDa member of the EGF family of peptide growth factors. It is further classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Mature HB-EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. The transmembrane form of HBEGF is a juxtacrine growth and adhesion factor and is uniquely the receptor for diphtheria toxin. Cells known to express HB-EGF include bronchial epithelium, visceral and vascular smooth muscle , CD4+ T cells, cardiac muscle, glomerular podocytes, keratinocytes and IL-10-secreting regulatory macrophages. HBEGF participates in diverse biological processes, including heart development and maintenance, skin wound healing, eyelid formation, blastocyst implantation, the progression of atherosclerosis, and tumor formation, through the activation of signaling molecules downstream of ErbB receptors and interactions with molecules associated with HBEGF. tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta markedly increased HB-EGF mRNA levels in HUVEC by 12- and 7-fold, respectively, and induction of the gene by TNF-alpha was both dose- and time-dependent.
          


           
          


          Product Properties
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          HBEGF, DT-R
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          Q99075
          
			          		
		
          
		
          
			
			
          GeneID
          
			          		
			
			
          1839
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          E.coli-derived Human HB-EGF, Asp63-Leu148.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Approximately 9.7 kDa.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
          
			          		
		
          
		
          
			
			
          Tag
          
			          		
			
			
          None
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 97% by SDS-PAGE and HPLC analyses.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/mL, corresponding to a specific activity of > 1.0 × 106 IU/mg. Fully biologically active when compared to standard.
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 130 mM NaCl.
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          


          Shipping and Storage
          


          The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          Cautions
          


          1. Avoid repeated freeze-thaw cycles.
          


          2. For your safety and health, please wear lab coats and disposable gloves for operation.
          


          3. For research use only!
          


           
          


          HB220225
          


           
          

             
           
           
           
           
           
           
           
          400-6111-883