问鼎娱乐.com|极速飞艇的冠亚和计划|极速赛车计划群群名|sg幸运飞艇计划官方版下载

<label id="6kt4j"></label>

    <li id="6kt4j"></li>
    1. 

          2. 
    
            
           
           
           
           
          Recombinant Human IL-17 Protein重組人白介素17
           
          更多活動(dòng)更多優(yōu)惠，盡在翌圣商城》
           
           
           
          批量采購(gòu)， 請(qǐng)點(diǎn)擊詢價(jià)
           
           
          產(chǎn)品說(shuō)明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          

          IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.
          


           
          


          Product Properties
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          Cytotoxic T-lymphocyte-associated antigen 8, CLTA-8 , IL-17A
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          Q16552
          
			          		
		
          
		
          
			
			
          GeneID
          
			          		
			
			
          3605
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          E.coli-derived human IL-17 protein,Gly24-Ala155.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Approximately 31.0 kDa.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA
          
			          		
		
          
		
          
			
			
          Tag
          
			          		
			
			
          None
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 95% by SDS-PAGE and HPLC analyses.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg 
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. 
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          


          Shipping and Storage
          


          The products are shipped with ice pack and can be stored at -20℃ for 1 year.
          


          1 month, 2 to 8 °C under sterile conditions after reconstitution.
          

          


          3 months, -20 °C under sterile conditions after reconstitution.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          Cautions
          


          1.Avoid repeated freeze-thaw cycles.
          


          2.For your safety and health, please wear lab coats and disposable gloves for operation.
          


          3.For research use only.
          


          HB221018
          


           
          

             
           
           
           
           
           
           
           
          400-6111-883