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          Recombinant Mouse GM-CSF Protein重組小鼠粒細胞巨噬細胞集落刺激因子
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
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          Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a powerful growth and differentiation factor which acts on hematopoietic progenitor cells and also activates differentiated granulocytes and macrophages. The 22 kDa glycosylated GMCSF, similar to IL3 and IL5, is a cytokine with a core of four bundled alpha -helices. Mature human GMCSF shares 63%70% amino acid sequence identity with canine, feline, porcine, and rat GMCSF and 54% with mouse GMCSF. GM-CSF has been and is still widely used as an adjuvant in clinical trials of vaccination with autologous tumor cells, peptides and/or dendritic cells in a variety of human neoplasms. The effects of GM-CSF on HIV-1 replication in primary monocytes and macrophages, and in related cell lines, have demonstrated augmentation of HIV-1 expression in vitro.
          


           
          


          Product Properties
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          Granulocyte/Macrophage Colony-Stimulating Factor, GM-CSF, CSF-2, MGI-1GM, Pluripoietin-α
          
			          		
		
          
		
          
			
			
          Accession
          
			          		
			
			
          P01587
          
			          		
		
          
		
          
			
			
          GeneID
          
			          		
			
			
          12981
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          E.coli-derived mouse GM-CSF protein, Ala18-Lys141.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          Approximately 14.1 kDa.
          
			          		
		
          
		
          
			
			
          AA Sequence
          
			          		
			
			
          APTRSPITVT RPWKHVEAIK EALNLLDDMP VTLNEEVEVV SNEFSFKKLT CVQTRLKIFE QGLRGNFTKL KGALNMTASY YQTYCPPTPE TDCETQVTTY ADFIDSLKTF LTDIPFECKK PGQK
          
			          		
		
          
		
          
			
			
          Tag
          
			          		
			
			
          None
          
			          		
		
          
		
          
			
			
          Physical Appearance
          
			          		
			
			
          Sterile Filtered White lyophilized (freeze-dried) powder.
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 98% by SDS-PAGE and HPLC analyses.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          The ED50 as determined by a cell proliferation assay using murine FDC-P1 cells is less than 0.05 ng/mL, corresponding to a specific activity of > 2.0 × 107 IU/mg. Fully biologically active when compared to standard. 
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 1.0 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. 
          
			          		
		
          
		
          
			
			
          Reconstitution
          
			          		
			
			
          We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20°C. Further dilutions should be made in appropriate buffered solutions.
          
			          		
		
          
	          

          


           
          

          


          Shipping and Storage
          


          The products are shipped with ice pack and can be stored at -20 ℃ for 1 year.
          


          1 month, 2 to 8 °C under sterile conditions after reconstitution.
          


          3 months, -20 °C under sterile conditions after reconstitution.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          Cautions
          


          1.Avoid repeated freeze-thaw cycles.
          


          2.For your safety and health, please wear lab coats and disposable gloves for operation.
          


          3.For research use only.
          


          HB221018
          

             
           
           
           
           
           
           
           
          400-6111-883