產(chǎn)品信息

產(chǎn)品名稱	貨號	規(guī)格
Recombinant Human sRANK Ligand/RANKL Protein	90633ES20	20 μg
	92286ES50	50 μg

 

產(chǎn)品描述

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells.

 

性能參數(shù)

分子別名	soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-related activation-inducedcytokine), OPGL, ODF (Osteoclast differentiation factor)
表達系統(tǒng)	E.coli
Accession Number	O14788
Gene ID	8600
氨基酸序列	MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTFSNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGSTKYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID
分子量	20 kDa
生物活性	Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells.
標簽	Tag Free
純度	> 98% by SDS-PAGE and HPLC analyses.
內(nèi)毒素	<0.01 EU/μg
制劑	1×PBS, pH 7.4
產(chǎn)品形態(tài)	凍干粉

 

儲存條件

2~8℃保存，有效期2年。

 

使用方法

一般用 無菌水在室溫下將蛋白干粉溶解成儲液，將蛋白等分，并儲存在-80℃。避免重復凍融循環(huán)。

 

注意事項

1. 本產(chǎn)品僅作科研用途。

2. 為了您的安全和健康，請穿實驗服并佩戴一次性手套操作。

 

Ver.CN20240329